Center of Brenham hospitality for 122 years. Originally a two-story log stage depot adjoined by a log cabin complex called the Washington County Hotel. Changed owners several times through the years. General Sam Houston once stayed here while campaigning against secession. Renamed St. Anthony Hotel 1914, by new owner Mrs.A.A. Hacker, who did extensive remodeling. Served as a transfer station for train passengers and as a bus terminal. Her hotel was noted for more than 30 years for its hospitality and annual Christmas Day open house and egg nog party.

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